Antimicrobial anaphylaxis: The changing face of severe antimicrobial allergy

V Hall; M Wong; M Munsif; BR Stevenson; K Elliott; M Lucas; AJ Baird; E Athan; M Young; R Pickles; AC Cheng; AJ Stewardson; AK Aung; JA Trubiano

Journal article

Antimicrobial anaphylaxis: The changing face of severe antimicrobial allergy

V Hall, M Wong, M Munsif, BR Stevenson, K Elliott, M Lucas, AJ Baird, E Athan, M Young, R Pickles, AC Cheng, AJ Stewardson, AK Aung, JA Trubiano

Journal of Antimicrobial Chemotherapy | Published : 2020

DOI: 10.1093/jac/dkz422

Abstract

Objectives: The epidemiology, clinical characteristics and outcomes of antimicrobial-associated anaphylaxis remain ill-defined. We sought to examine antimicrobial anaphylaxis with regard to: (i) the frequency of implicated antimicrobials; (ii) attributable mortality; and (iii) referral for definitive allergy assessment. Methods: This was conducted through a national retrospective multicentre cohort study at five Australian tertiary hospitals (January 2010 to December 2015). Cases of antimicrobial anaphylaxis were identified from ICD-10 coding and adverse drug reaction committee databases. Results: There were 293 participants meeting the case definition of antimicrobial anaphylaxis and 310 an..

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University of Melbourne Researchers

Eugene Athan Author

Jason Trubiano Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship (GNT 1139902 to J.A.T.) and a postgraduate scholarship from The National Centre for Infections in Cancer, National Health and Medical Research Council, Centre for Research Excellence (GNT 1116876 to J.A.T.).